Observations on the epidemiology of simple hypospadias.

نویسندگان

  • C J Roberts
  • S Lloyd
چکیده

A descriptive epidemiological study of simple hypospadias-that is, hypospadias without coexisting malformation outside the genital system-in a birth population of 46,927 singleton males and 1,013 twin males showed that the condition was significantly more common (P < 0.001) in uniovular twin males than in either singleton or binovular twin males. Also the temporal distribution of dates of conception had a significant cyclic pattern for each year of the study. Both observations are thought to support the view that gonadotrophin levels at stage 3 sexual organogenesis play an important part in normal masculinization of male external genitalia.

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عنوان ژورنال:
  • British medical journal

دوره 1 5856  شماره 

صفحات  -

تاریخ انتشار 1973